Gary Wayne Zachary, 30, was shot to death at about 1:10 a.m. in the 700 block of Fenell.
He died at Ben Taub Hospital, HPD officials said.
The suspects are identified as Roberto Arredondo and Raphael Garza Duenez. Duenez also uses an alias of Jair Alejandro Salas. Both are charged with capital murder.
HPD said Zachary was shot inside one of three houses located at 716 Fenell. Investigators determined the house located at the rear of the lot was being used to manufacture and sell narcotics and that the shooting was likely the result of a home invasion.
Witnesses told police two Hispanic male suspects went inside and demanded money. A struggle between Zachary and the suspects ensued, and he was shot.
One of the males, Arredondo, was being treated for a gunshot wound to the back at Methodist Hospital. Officers took a witness statement from him at the hospital. It's believed he was shot during the struggle.
Once investigators had enough evidence to pursue charges and identify Arredondo and Duenez as suspects, the investigators learned Arredondo had left Methodist Hospital on March 29 with an IV still in his arm.
Anyone with information on the whereabouts of suspects Arredondo and Duenez is urged to contact the HPD Homicide Division at (713) 308-3600 or Crime Stoppers at (713) 222-TIPS.